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Anti -HECTD1 Rabbit pAb

货号:GB111394

品牌:Servicebio

价格:¥650

规格: 100 μl

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Product Information

 

 

Description

HECTD1 rabbit polyclonal

Protein full name E3 ubiquitin-protein ligase HECTD1

Synonyms

HECT domain-containing protein 1, HECT-type E3 ubiquitin transferase HECTD1, Protein open mind, Hectd1, Kiaa1131, Opm

Immunogen Recombinant protein corresponding to
Mouse HECTD1
Isotype IgG
Purity Affinity purification
Subcellular location Cytoplasm, Nucleus
Uniprot ID
Q69ZR2
 

 


 

Applications

 

 

Applications IHC,IF
Species Rat,Rat
Dilution 1: 1000-1: 2000,1: 1000-1: 2000
Positive Tissue brain,skeletal muscle, brain

 


 

Background

HECTD1 (E3 ubiquitin-protein ligase, which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates . Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion . Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells impairs their emigration and is consequently essential for the correct development of the cranial neural folds and neural tube closure.It is also involved in sporadic Parkinson’s disease.
 


 

Images

 

Immunohistochemistry analysis of paraffin-embedded rat brain using
HECTD1 (GB111394) at dilution of 1: 2000
 

Immunofluorescent analysis of paraformaldehyde-fixed rat skeletal muscle using HECTD1 (GB111394) at dilution of
1: 2000
 

Immunofluorescent analysis of paraformaldehyde-fixed rat brain using
HECTD1 (GB111394) at dilution of 1: 2000
 

 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.