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Anti -Occludin Rabbit pAb

货号:GB111401

品牌:Servicebio

价格:¥650

规格: 100 μl

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Product Information

 

 

Description

Occludin rabbit polyclonal

Protein full name Occludin

Synonyms

OCLN, Tight junction protein occludin, PTORCH1, PPP1R115, Phosphatase 1 regulatory subunit 115, Ocln, MGC34277

Immunogen KLH conjugated Synthetic peptide
corresponding to Human Occludin
Isotype IgG
Purity Affinity purification
Subcellular location Cell membrane
Predicted MW. 59 kDa
Observed MW. 59 kDa
Uniprot ID Q16625, Q61146, Q6P6T5

 


 

Applications

 

 

Applications WB,IHC,IF
Species Mouse, Rat,Mouse, Rat,Human, Mouse, Rat
 
Dilution 1: 500-1: 1000,1: 500-1: 1000,1: 500-1: 1000
Positive Tissue colon, brain, kidney,ovary cancer, colon cancer, colon,appendix, esophageal cancer, colon cancer, breast cancer, kidney cancer, small intestine, colon

 


 

Background

Occludin is an integral membrane protein located at the tight junction. It is a tetraspanin protein with four transmembrane domains, intracellular N and C termini and two extracellular loops. Occludin plays a role in the formation and regulation of the tight junction paracellular permeability barrier. Under-expression of tight junction proteins is a key molecular abnormality responsible for the increased permeability of tumor endothelial tight junctions, which contributes to brain tumor edemas.
 


 

Images

 

Western blot analysis of Occludin (GB111401) at dilution of 1: 1000
Lane 1: Mouse colon tissue lysate
Lane 2: Mouse brain tissue lysate
Lane 3: Mouse kidney tissue lysate
Lane 4: Rat brain tissue lysate

 

Immunohistochemistry analysis of paraffin-embedded human ovary cancer using Occludin (GB111401) at dilution of 1: 750
 

Immunohistochemistry analysis of paraffin-embedded human colon cancer using
Occludin (GB111401) at dilution of 1: 750
 

Immunohistochemistry analysis of paraffin-embedded rat colon using
Occludin (GB111401) at dilution of 1: 750
 

Immunofluorescent analysis of paraformaldehyde-fixed human appendix using Occludin (GB111401) at dilution of 1: 750
 

Immunofluorescent analysis of paraformaldehyde-fixed human esophageal cancer using Occludin (GB111401) at dilution of 1: 750
 

Immunofluorescent analysis of paraformaldehyde-fixed human colon cancer using Occludin (GB111401) at dilution of 1: 750
 

Immunofluorescent analysis of paraformaldehyde-fixed human breast cancer using Occludin (GB111401) at dilution of 1: 750
 

Immunofluorescent analysis of paraformaldehyde-fixed human kidney cancer using Occludin (GB111401) at dilution of 1: 750
 

Immunofluorescent analysis of paraformaldehyde-fixed mousesmall intestine using Occludin (GB111401) at dilution of 1: 750
 

Immunofluorescent analysis of paraformaldehyde-fixed rat small intestine using
Occludin (GB111401) at dilution of 1: 750
 

Immunofluorescent analysis of paraformaldehyde-fixed rat colon using
Occludin (GB111401) at dilution of 1: 750
 

 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.